Characterization of Mitochondrial Imidazoline-Guanidinium Receptive Sites (IGRS) in Liver
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چکیده
منابع مشابه
Visualization of multiple imidazoline/guanidinium-receptive sites.
Compounds with an imidazoline or guanidinium moiety elicit a variety of stimulatory and inhibitory cell responses in both central and peripheral tissues. Many of these effects are mediated by interaction with alpha-adrenergic receptors, but these molecules also selectively recognize other membrane-bound proteins with high affinity. We used a functionalized derivative of the imidazoline molecule...
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The imidazoline-guanidinium receptive site (IGRS) is a membrane-bound protein that may mediate some of the pharmacological effects of imidazoline and guanidinium compounds. The structure and functionality of this protein are unknown but, in addition to its location at the plasma membrane, it is found in high density in the outer membrane of mitochondria (Tesson, F., Prip-Buus, C., Lemoine, A., ...
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Radioligand binding experiments were carried out to identify and characterize nonadrenoceptor [3H]idazoxan binding sites and [3H](1, 2-di-(2-tolyl)guanidine) binding sites in the rat and human stomach. Furthermore, we examined two selected aspects of their potential functional significance. Binding of [3H]idazoxan (Kd = 11.1 nM and 12.4 nM, respectively) and [3H]DTG (Kd = 932 nM and 242 nM, res...
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Radioligand binding experiments were carried out to identify and characterize nonadrenoceptor [H]idazoxan binding sites and [H](1,2-di-(2-tolyl)guanidine) binding sites in the rat and human stomach. Furthermore, we examined two selected aspects of their potential functional significance. Binding of [H]idazoxan (Kd 5 11.1 nM and 12.4 nM, respectively) and [H]DTG (Kd 5 932 nM and 242 nM, respecti...
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properties of agmatine and endogenous clonidine-displacing substance at imidazoline and alpha-2 adrenergic receptors. A. Imidazoline-guanidinium receptive site in renal proximal tubule: asymmetric distribution, regulation by cations and interaction with an endogenous clonidine displacing substance.idazoxan label different populations of imidazoline sites on rat kidney.
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ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 1992
ISSN: 1941-7225,0895-7061
DOI: 10.1093/ajh/5.4.80s